Terrein Inhibits Aggressive Phenotype of A549 Human Lung Cancer Cell through Suppression of HIF-1α

Terrein is a fungal metabolite that has already been reported with anticancer properties. However, the effect on aggressive phenotype of cancer cells not elucidated yet. In present study, cytotoxicity terrein was first determined against lung (A549) model and compared several normal cell lines (Vero, L6, H9C2 cells). The data demonstrated had specific A549 relative to high selectivity index values. Then, hypoxic recognized induce abilities established in by cobalt chloride (CoCl2) stimulation. With this model, could reduce HIF-1α, marker hypoxia, inhibit both migration invasion which more explicit. Our results potential new role as anti-aggressive inhibiting through HIF-1α reduction. HIGHLIGHTS Terrein, secondary bioactive extracted from Aspergillus terreus, demonstrates less cytotoxic CoCl2 treatment successfully used for creating resulting HIF-1a augmentation enhancement expression invasive ability anti-metastatic agent GRAPHICAL ABSTRACT